Lucas Arnoldt

About

I'm a PhD student in Fabian Theis' lab at Helmholtz Munich, supported by the German National Scholarship Foundation. My work sits at the intersection of deep learning and genomics, where I am building models that are not only accurate but interpretable.

I'm always happy to chat about research, collaborations, or ideas. Feel free to reach out.

Research Interests

Publications

• Preprint

  annbatch unlocks terabyte-scale training of biological data in anndata

  Gold I.^#, Fischer F.^#, Arnoldt L., Wolf F.A., Theis F.J.

  arXiv (2026) · doi: 10.1101/2025.06.10.657924

• Published · Lancet Digital Health

  A Predictive Atlas of Disease Onset from Retinal Fundus Photographs

  Buergel T.^#, Loock L.^#, Steinfeldt J.^#, …, Arnoldt L., …, Wild B., Eils R.

  Lancet Digital Health (2026) · doi: 10.1016/j.landig.2025.100962

• Preprint

  Integration of Multimodal Single-Cell Data via Explainable Sparse Deep Generative Modelling

  Arnoldt L., Upmeier zu Belzen J., Herrmann L., Nguyen K., Ishaque N., Theis F.J., Wild B., Eils R.

  bioRxiv (2025) · doi: 10.1101/2025.06.10.657924

• Published · Nature Biotechnology

  Multistate and Functional Protein Design Using RoseTTAFold Sequence Space Diffusion

  Lisanza S.L.^#, Gershon J.M.^#, Tipps S.W.K.^#, Sims J.N.^#, Arnoldt L.^#, Hendel S.J., … Baker D.

  Nature Biotechnology (2024) · doi: 10.1038/s41587-024-02395-w

Software